NEW PARKINSON THERAPY ENABLES CONTINUOUS DOPAMINERGIC STIMULATION
Duodopa® is a new parkinson therapy that imitates a normally functioning dopamine system. The drug is based on the latest scientific findings on potential positive long-term effects of continuous dopaminergic stimulation. By supplying the body with a constant and even dopamine flow, Duodopa has shown significantly better results in the treatment of advanced Parkinson’s disease compared with different combination of medication.

DUODOPA – LEVODOPA AND CARBIDOPA
The active ingredients of Duodopa are two well-documented substances, levodopa and carbidopa, which are dispersed in a viscous gel. A portable, patient-operated pump delivers the drug through a tube directly into the gastrointestinal tract (duodenum), which ensures more even supply and uptake compared with tablet treatment.

Duodopa is based on more than ten years of clinical experience. Comprehensive clinical studies show that the patient’s mobility is significantly increased. This substantially improves the patient’s quality of life.

NOVEL METHODS OF TREATMENT WITH PATENTED DRUG-DELIVERY TECHNOLOGY
Solvay Pharmaceuticals is committed to improving the existing drug-delivery technology in order to provide better accepted medical devices and better quality of life. Known active substances, components and technologies can be applied in a way that adds value to healthcare.

RESEARCH AND PRODUCT DEVELOPMENT

Solvay Pharmaceuticals have a strong internal and external organization for applied research and product development. The company’s international marketing is based in Hannover, Germany, and is constantly researching to introduce innovative medicinal formulations and systems.

RECENT PUBLICATIONS

Publication title / authors / source.

Continuous Intra-intestinal Infusion of Levodopa/Carbidopa in Advanced Parkinson’s Disease / Dag Nyholm and Per Odin / 2007; 44-48
Duodenal Levodopa Infusion for Advanced Parkinson’s Disease: 12-Month Treatment Outcome / Antonini A. et al. / Mouv. Dis. 2007; 22(8):1145-1149
Pedal : Identification of Models for Duodenal Administration of Levodopa / Westin J. et al. / Eur. J. of Neurology, 2007; 13:S2
Duodenal Levodopa Infusion for the Treatment of Parkinson‘s Disease / Samanta J. et Hauser R.A. / Expert Opin. Pharmacother. 2007; 8(5):657-664
Continuous Levodopa for Advanced Parkinson’s Disease / Lundqvist C. / Neuropsychiatric Dis. & Treat., 2007; 3(3): 1–14
Pharmacokinetic Optimisation in the Treatment of Parkinson’s Disease / Nyholm D. / Clin. Pharmacokinet. 2006; 45(2):109-136
Enteral Levidopa/Carbidopa Gel Infusion for the Treatment of Motor Fluctuations and Dyskinesias in Advanced Parkinson’s Disease / Nyholm D. / Expert Rev. Neurotherapeutics, 2006; 6(10) 1403-1411
Drug Insight: Continuous Dopaminergic Stimulation in the Treatment of Parkinson’s Diseases / Olanow C.W. et al. / Nature Clinical Practice Neurology, 2006; 2(7): 382-392
Solvay Pharmaceuticals
Hans-Boeckler-Alee, 20
30173 Hannover
Germany
Tel: +49 511 8573537
Fax: +49 511 8572294
Email: stefan.asberg@solvay.com
Email: leslie.kuester@solvay.com
Email: claudio.sandner@solvay.com
URL: www.solvaypharmaceuticals.com

Formed in 1994, Galentic’s initially focused on producing ointments and creams. This moved on to ophthalmic ointments and other topical products in 1995. The company’s pharmaceutical production facilities are ISO 9001: 2000 certified by the German TUV Bayern agency and meet GMP requirements for sterile ointment manufacturing (capacity of 85,000 tubes per day).

PHARMACEUTICAL MANUFACTURING CAPACITY
Galentic’s state-of-the-art manufacturing plant produces 135Mt of creams and 25 million tubes of sterile ointment on an annual basis. The company also manufacture various types of creams and ointments for topical application, and have WHO Good Manufacturing Practice (GMP) certificates for various products.

EYE OINTMENT PRODUCTS
Galentic supplies a wide range of eye ointments for a variety of ophthalmic infections. The product range includes aciclovir eye ointment, chloramphenicol ophthalmic ointment, gentamicin sulphate ophthalmic ointment, hydrocortisone acetate ophthalmic ointment, tetracycline hydrochloride ophthalmic eye ointment USP 1%, netracycline eye ointment (oxytetracycline eye ointment), oxytetracycline hydrochloride and hydrocortisone ophthalmic eye ointment, triosporin antibiotic eye ointment and sulphacetamide sodium ophthalmic ointment.

SKIN OINTMENT / CREAM PRODUCTS
Galentic actively develops new skin ointment and cream products for the pharmaceutical and healthcare industries, including:

Betamethasone valerate cream
Betamethasone dipropionate cream
Clobetasol propionate ointment / cream
Clotrimazole cream
Betamethasone dipropionate with gentamicin sulphate
Clotrimazole cream diclofenac gel
Fluocinolone acetonide and neomycin sulphate cream
Hydrocortisone acetate ointment/cream
Miconazole cream/ointment
Silver sulfadiazine cream
Tetracycline hcl ointment
Compound benzoic acid ointment / Whitfield’s ointment
Whitefield’s ointment
Econazole cream
Ketoconazole cream
Ointment of menthol and methyl salicylate ointment
Tolnaftate cream
Neomycin sulphate / Bacitracin zinc ointment
FURTHER OINTMENTS AND GELS
Galentic also manufactures zinc oxide ointment (5% and 25%), anti-haemorrhoid ointment, tiabendazole ointment, hydrocortisone and urea cream, fluocinole ointment, salicylic acid ointment, dexamethasone acetate and clotrimazole cream, griseofulvin ointment, white petroleum jelly (sterile or non-sterile), diclofenac diethylammonium oleum lini methyl salicylate and menthol gel (rubigel), nystatin cream / ointment, salicylic acid and precipitated sulphur ointment, fucidic acid cream, aciclovir cream and diclofenac gel.

Rubigel ointment is used to reduce backache, joint pains, sprains and muscle cramp, as well as offering faster penetration of active medication thereby providing faster onset of pain relief; versept cream is used for cleansing and antisepsis of skin and mucous membranes that include wounds, burns, ulcers and abcesses. Avalon NF skin cream is a combination of Neomyci and Fluocinolone acetonide that is used for topical application.

LOTION, APPLICATION, EMULSION AND SOLUTION PRODUCTS
Galentic manufacture the following lotion, application, emulsion and solutions: betamethasone dipropionate and salicylic acid lotion, benzyl benzoate application, calamine lotion, acriflavin emulsion and chlorhexidine gluconate solution

The company also offers anti-haemorrhoid ointment for haemorrhoid patients. Betamethosone valerate ointment is used for anti-inflammatory effect; phenylephrine HCL ointment reduces bleeding and swelling, and relieves itching and discomfort by tightening the blood vessels. Lidocaine HCL local anaesthetic ointment provides fast, effective and lasting pain relief.

VETERINARY PHARMACEUTICAL PRODUCTS
Galentic also manufactures products for use in veterinary healthcare, including gamma benzene hexachloride and proflavine hemisulphate with cemtrimide cream, neomycin sulphate and zinc bacitracin skin ointment, neomycin and polymyxin B sulphates and bacitracin zinc ointment USP, and tetracycline eye ointment 1% 10gm.

Galentic Pharma India Pvt Ltd
445, A-1 Shah and Nahar Industrial Estate
Sitaram Jadhav Marg
Lower Parel
Mumbai – 400 013
India
Tel: +91 22 2490 14 94
Fax: +91 22 2490 19 19
Email: galentic@vsnl.com
URL: www.galentic.com